Routine
Molecular
CellSight ™ DNA
Test code CELL-SIGHT-DNACPT 81459Turnaround 10 to 14 days from specimen receipt
Test description
A comprehensive genomic profiling test performed on intact circulating tumor cells, not DNA fragments, from a single blood draw. 517-gene panel; reported alterations: single nucleotide variants (SNVs), insertions and deletions (indels), copy number variants (CNVs). Signatures: tumor mutational burden (TMB) and microsatellite instability (MSI). Enumeration: CTC count reported for the entire patient accession. Validated across a range of solid tumors. Laboratory-developed test; not cleared or approved by the U.S. FDA.
Test methodology
Next-Generation Sequencing
Genes tested
517 genes- A1CF
- ABCB1
- ABL1
- ABL2
- ABRAXAS1
- ACSM2B
- ACVR1
- ACVR1B
- ACVR2A
- ADAM18
- ADAMTS12
- ADAMTS2
- AKT1
- AKT2
- AKT3
- ALK
- AMER1
- ANO4
- APC
- AR
- ARAF
- ARHGAP35
- ARID1A
- ARID1B
- ARID2
- ARID5B
- ASXL1
- ASXL2
- ATM
- ATP1A1
- ATR
- ATRX
- AURKA
- AURKB
- AURKC
- AXIN1
- AXIN2
- AXL
- B2M
- BAP1
- BARD1
- BCL2
- BCL2L12
- BCL6
- BCOR
- BCR
- BLM
- BMP5
- BMPR2
- BRAF
- BRCA1
- BRCA2
- BRINP3
- BRIP1
- BTK
- C6
- C8A
- C8B
- CACNA1D
- CALR
- CANX
- CARD11
- CASP8
- CASR
- CBFB
- CBL
- CCND1
- CCND2
- CCND3
- CCNE1
- CD163
- CD274
- CD276
- CD79B
- CDC73
- CDH1
- CDH10
- CDK12
- CDK4
- CDK6
- CDKN1A
- CDKN1B
- CDKN2A
- CDKN2B
- CDKN2C
- CHD4
- CHEK1
- CHEK2
- CIC
- CIITA
- CNTN6
- CNTNAP4
- CNTNAP5
- COL11A1
- CREBBP
- CSF1R
- CSMD3
- CTCF
- CTLA4
- CTNNB1
- CTNND2
- CUL1
- CUL3
- CUL4A
- CUL4B
- CYLD
- CYP2C9
- CYP2D6
- CYSLTR2
- DAXX
- DCAF4L2
- DCDC1
- DDR1
- DDR2
- DDX3X
- DGCR8
- DICER1
- DNMT3A
- DOCK3
- DPYD
- DROSHA
- DSC1
- DSC3
- E2F1
- EGFR
- EIF1AX
- ELF3
- EMSY
- ENO1
- EP300
- EPAS1
- EPCAM
- EPHA2
- ERAP1
- ERAP2
- ERBB2
- ERBB3
- ERBB4
- ERCC2
- ERCC4
- ERCC5
- ERG
- ERRFI1
- ESR1
- ETV1
- ETV4
- ETV5
- ETV6
- EZH2
- FAM135B
- FANCA
- FANCC
- FANCD2
- FANCE
- FANCF
- FANCG
- FANCI
- FANCL
- FANCM
- FAS
- FAT1
- FBXW7
- FGF19
- FGF23
- FGF3
- FGF4
- FGF7
- FGF9
- FGFR1
- FGFR2
- FGFR3
- FGFR4
- FLT3
- FLT4
- FOXA1
- FOXL2
- FOXO1
- FUBP1
- FYN
- GALNT17
- GATA2
- GATA3
- GLI1
- GLI3
- GNA11
- GNA13
- GNAQ
- GNAS
- GPR158
- GPS2
- GRID2
- H1-4
- H2BC5
- H3-3A
- H3-3B
- H3C2
- HCN1
- HDAC2
- HDAC9
- HIF1A
- HLA-A
- HLA-B
- HLA-C
- HNF1A
- HRAS
- ID3
- IDH1
- IDH2
- IGF1R
- IKBKB
- IL6ST
- IL7R
- INPP4B
- IRF4
- IRS4
- JAK1
- JAK2
- JAK3
- KCND2
- KCNH7
- KCNJ5
- KDM5C
- KDM6A
- KDR
- KEAP1
- KEL
- KIR3DL1
- KIT
- KLF4
- KLF5
- KLHL13
- KMT2A
- KMT2B
- KMT2C
- KMT2D
- KNSTRN
- KRAS
- KRTAP21-1
- KRTAP6-2
- LARP4B
- LATS1
- LATS2
- LRRC7
- MAGOH
- MAP2K1
- MAP2K2
- MAP2K4
- MAP2K7
- MAP3K1
- MAP3K4
- MAP3K8
- MAPK1
- MAPK8
- MARCO
- MAX
- MCL1
- MDM2
- MDM4
- MECOM
- MED12
- MEF2B
- MEN1
- MET
- MGA
- MITF
- MLH1
- MLH3
- MPL
- MRE11
- MSH2
- MSH3
- MSH6
- MTAP
- MTOR
- MTUS2
- MUTYH
- MYB
- MYBL1
- MYC
- MYCL
- MYCN
- MYD88
- MYOD1
- NBN
- NCOR1
- NF1
- NF2
- NFE2L2
- NLRC5
- NOL4
- NOTCH1
- NOTCH2
- NOTCH3
- NOTCH4
- NRAS
- NRG1
- NRXN1
- NSD2
- NT5C2
- NTRK1
- NTRK2
- NTRK3
- NUP93
- NUTM1
- NYAP2
- ODAD2
- OR10G8
- OR2G6
- OR2L13
- OR2L2
- OR2L8
- OR2M3
- OR2T3
- OR2T33
- OR2T4
- OR2W3
- OR4A15
- OR4C15
- OR4C6
- OR4M1
- OR4M2
- OR5D18
- OR5F1
- OR5L1
- OR5L2
- OR6F1
- OR8H2
- OR8I2
- OR8U1
- ORC4
- PAK5
- PALB2
- PARP1
- PARP2
- PARP3
- PARP4
- PAX5
- PBRM1
- PCBP1
- PCDH17
- PDCD1
- PDCD1LG2
- PDE1A
- PDE1C
- PDGFRA
- PDGFRB
- PDIA3
- PGD
- PHF6
- PIK3C2B
- PIK3CA
- PIK3CB
- PIK3CD
- PIK3CG
- PIK3R1
- PIK3R2
- PIM1
- PLCG1
- PLXDC2
- PMS1
- PMS2
- POLD1
- POLE
- POM121L12
- POT1
- PPARG
- PPFIA2
- PPM1D
- PPP2R1A
- PPP2R2A
- PPP6C
- PRDM1
- PRDM9
- PRKACA
- PRKACB
- PRKAR1A
- PSMB10
- PSMB8
- PSMB9
- PTCH1
- PTEN
- PTPN11
- PTPRD
- PTPRT
- PXDNL
- RAC1
- RAD50
- RAD51
- RAD51B
- RAD51C
- RAD51D
- RAD52
- RAD54L
- RAF1
- RARA
- RASA1
- RASA2
- RB1
- RBM10
- RBP3
- RECQL4
- REG1A
- REG1B
- REG3A
- REG3G
- RELA
- RET
- RGS7
- RHEB
- RHOA
- RICTOR
- RIT1
- RNASEH2A
- RNASEH2B
- RNASEH2C
- RNF43
- ROS1
- RPA1
- RPL10
- RPL22
- RPL5
- RPS6KB1
- RPTN
- RPTOR
- RSPO2
- RSPO3
- RUNDC3B
- RUNX1
- RUNX1T1
- SDHA
- SDHB
- SDHC
- SDHD
- SETBP1
- SETD2
- SF3B1
- SH3RF2
- SIX1
- SIX2
- SLC15A2
- SLC8A1
- SLCO1B3
- SLX4
- SMAD2
- SMAD4
- SMARCA4
- SMARCB1
- SMC1A
- SMO
- SNCAIP
- SOCS1
- SOS1
- SOX2
- SOX9
- SPEN
- SPOP
- SRC
- SRSF2
- STAG2
- STAT1
- STAT3
- STAT5B
- STAT6
- STK11
- SUFU
- SYT10
- SYT16
- TAF1
- TAP1
- TAP2
- TAPBP
- TBX3
- TCF7L2
- TERT
- TET2
- TFE3
- TFEB
- TGFBR1
- TGFBR2
- TMEM132D
- TNFAIP3
- TNFRSF14
- TOP1
- TOP2A
- TP53
- TP63
- TPMT
- TPP2
- TPTE
- TRHDE
- TRIM48
- TRIM51
- TRRAP
- TSC1
- TSC2
- TSHR
- U2AF1
- UGT1A
- USP8
- USP9X
- VHL
- WAS
- WT1
- XPO1
- XRCC2
- XRCC3
- YAP1
- YES1
- ZBTB20
- ZFHX3
- ZIM3
- ZMYM3
- ZNF217
- ZNF429
- ZNF479
- ZNF536
- ZRSR2
Specimen requirements
- Specimen type
- Whole blood
- Container
- CellSave CTC Preservation Tubes (kit supplied)
- Volume
- Two 10 mL CellSave CTC Preservation Tubes
- Collection
- Specimen: Peripheral whole blood
- Rejection criteria
- Streck and EDTA tubes are not accepted.
Storage & transportation
Room temp
15–25 °C
Not specified
Refrigerated · preferred
2–8 °C
Not specified
Frozen
−20 °C
Not specified
- Transport temperature
- Refrigerated (2–8 °C)
- Shipping instructions
- Shipped chilled at 2 to 8 °C. Schedule sample pick-up with the lab's logistics team.